Application of the Henderson-Hasselbalch Equation to Solubility Determination
نویسندگان
چکیده
منابع مشابه
pKa values in solubility determination using the Henderson- Hasselbalch equation
Alex Avdeef [1] and Samuel Yalkowsky [2] have independently studied the solubility and ionization properties of an investigational drug (NSC-639829). In the study conducted by Avdeef and coworkers, the pKa value derived from Henderson-Hasselbalch (HH) equation was 4.70, which was different from the value of 3.76 as determined experimentally by the Yasuda-Shedlovsky plot using the pKa values obt...
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ژورنال
عنوان ژورنال: ADMET & DMPK
سال: 2015
ISSN: 1848-7718
DOI: 10.5599/admet.3.4.209